Ontology highlight
ABSTRACT:
SUBMITTER: Piccolo FM
PROVIDER: S-EPMC6957317 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
eLife 20191223
Methyl-CpG-binding-Protein 2 (MeCP2) is an abundant nuclear protein highly enriched in neurons. Here we report live-cell single-molecule imaging studies of the kinetic features of mouse MeCP2 at high spatial-temporal resolution. MeCP2 displays dynamic features that are distinct from both highly mobile transcription factors and immobile histones. Stable binding of MeCP2 in living neurons requires its methyl-binding domain and is sensitive to DNA modification levels. Diffusion of unbound MeCP2 is ...[more]