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Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients.


ABSTRACT: The role of body weight change in survival among recipients of hematopoietic stem-cell transplantation is controversial. We assessed the effect of optimizing energy and protein intake on 1-year survival, body weight and body composition, and the effect of body weight and body composition on 1-year survival in 117 patients (57 intervention, 60 control) in a randomized controlled trial. Cox regression was used to study effects of the intervention, weight and body composition on death, relapse, and nonrelapse mortality (NRM). We found no significant effect of intervention versus control on death hazard ratio (HR) 1.05, 95% confidence interval (CI) 0.54-2.04, p?=?0.88), relapse (HR 1.15, 95% CI 0.48-2.27, p?=?0.75), and NRM (HR 0.95, 95% CI 0.39-2.28, p?=?0.90). Body weight, fat-free mass index, body fat mass index and total body water changed over time (p?

SUBMITTER: Skaarud KJ 

PROVIDER: S-EPMC6957463 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients.

Skaarud K J KJ   Veierød M B MB   Lergenmuller S S   Bye A A   Iversen P O PO   Tjønnfjord G E GE  

Bone marrow transplantation 20190827 12


The role of body weight change in survival among recipients of hematopoietic stem-cell transplantation is controversial. We assessed the effect of optimizing energy and protein intake on 1-year survival, body weight and body composition, and the effect of body weight and body composition on 1-year survival in 117 patients (57 intervention, 60 control) in a randomized controlled trial. Cox regression was used to study effects of the intervention, weight and body composition on death, relapse, and  ...[more]

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