Differential gene expression profile analysis in corticosterone-treated PC12 cells.
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ABSTRACT:
SUBMITTER: Zhao JJ
PROVIDER: S-EPMC6958082 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Differential gene expression profile analysis in corticosterone-treated PC12 cells.
Zhao Jing-Jie JJ Zhang Ping P Li Li L Chen Shu-Xing SX Joines Allison A Wu Donald D Wong Megan M Shahan Justin J Golden Teresa T Wu Ning N Li Ming-Zhen MZ
International journal of clinical and experimental pathology 20180601 6
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder that has been ranked as the 4th leading cause of disability worldwide. Past clinical and laboratory evidence has confirmed that abnormalities of the hypothalamic-pituitary-adrenal (HPA)-axis are involved in MDD development. In this study, we took advantage of corticosterone treatment of PC12 cells as a model to identify genes regulated by HPA-axis hormones. Next-generation RNA-Seq technology was utilized to explore genome ...[more]
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