Dataset Information

Association between the GPAM rs1129555 SNP and serum lipid profiles in the Maonan and Han populations.

ABSTRACT: The glycerol-3-phosphate acyltransferase mitochondrial gene (GPAM) variant has been associated with serum lipid levels in the Eurpean ancestry, but little is known about such association in Chinese populations. The aim of the present study was to investigate the relationship between the GPAM rs1129555 single nucleotide polymorphism (SNP) and several environment factors with blood lipid profiles in the Guangxi Maonan and Han populations. A total of 720 individuals of Maonan nationality and 780 participants of Han nationality were randomly selected from our previous stratified randomized samples. Genotyping of the rs1129555 SNP was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique, and then confirmed by direct sequencing. The frequencies of C and T alleles were 72.85% and 27.15% in Maonan, and 65.19% and 34.81% in Han (P < 0.001); respectively. The frequencies of CC, CT, and TT genotypes were 51.53%, 42.36%, and 5.97% in Maonan, and 43.08%, 44.23%, and 12.69% in Han populations (P < 0.001). The T allele carriers had higher serum triglyceride (TG) in Han and higher low-density lipoprotein cholesterol (LDL-C) in both Maonan and Han than the T allele non-carriers (P < 0.05-0.01). Gender subgroup analyses showed that the T allele carriers had higher TG levels in Han males (P < 0.05) and higher LDL-C levels in Maonan males but not in famales (P < 0.01). Serum lipid parameters were also associated with several environmental factors (P < 0.05-0.001). These findings suggest that racial/ethnic- and/or gender-specific association occurs between the GPAM rs1129555 variant and serum lipid parameters in our study populations.

SUBMITTER: Yang S

PROVIDER: S-EPMC6958110 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Association between the GPAM rs1129555 SNP and serum lipid profiles in the Maonan and Han populations.

Yang Shuo S Yin Rui-Xing RX Miao Liu L Zhang Qing-Hui QH Zhou Yong-Gang YG Wu Jie J

International journal of clinical and experimental pathology 20180301 3

The glycerol-3-phosphate acyltransferase mitochondrial gene (GPAM) variant has been associated with serum lipid levels in the Eurpean ancestry, but little is known about such association in Chinese populations. The aim of the present study was to investigate the relationship between the GPAM rs1129555 single nucleotide polymorphism (SNP) and several environment factors with blood lipid profiles in the Guangxi Maonan and Han populations. A total of 720 individuals of Maonan national ...[more]

PMID: 31938246

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Project description:BackgroundNiemann-pick C1-like 1 (NPC1L1) is a key protein for intestinal cholesterol transportation. Common single nucleotide polymorphisms (SNPs) in the NPC1L1 gene have been associated with cholesterol absorption and serum lipid levels. The present study was undertaken to explore the possible association of NPC1L1 rs2072183 1735 C > G SNP and several environmental factors with serum lipid levels in the Mulao and Han populations.MethodsGenotyping of the rs2072183 SNP was performed in 688 subjects of Mulao and 738 participants of Han Chinese. The interactions between NPC1L1 1735 C > G polymorphism and several environmental factors on serum lipid phenotypes were tested using the factorial design covariance analysis after controlling for potential confounders.ResultsThe frequency of G allele was lower in Mulao than in Han (29.72% vs. 37.26%, P < 0.001). The frequency of CC, CG and GG genotypes was 49.85%, 40.84% and 9.31% in Mulao, and 39.30%, 46.88% and 13.82% in Han (P < 0.001); respectively. The levels of low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) B and the ratio of ApoAI/ApoB in Han but not in Mulao were different among the three genotypes (P < 0.05 for all), the subjects with GG and CG genotypes had higher LDL-C, ApoB levels and lower ApoAI/ApoB ratio than the subjects with CC genotype. Subgroup analysis showed that the G allele carriers in Han had higher total cholesterol (TC), LDL-C and ApoB levels in males (P < 0.05) and lower ApoAI/ApoB ratio in both sexes (P < 0.05) than the G allele noncarriers. The G allele carriers in Mulao had higher TC and LDL-C levels in males (P < 0.05) and lower high-density lipoprotein cholesterol (HDL-C) levels in both sexes (P < 0.05) than the G allele noncarriers. Serum TC, LDL-C, ApoB levels and ApoAI/ApoB ratio were correlated with genotypes in Han males (P < 0.05) but not in females. Serum lipid parameters were also correlated with several environmental factors. The genotypes of rs2072183 SNP were interacted with gender or cigarette smoking to influence serum TC and HDL-C levels in Mulao, whereas the genotypes of rs2072183 SNP were interacted with several environmental factors to influence all seven lipid traits in Han (P < 0.05-0.01).ConclusionsThe present study suggests that the rs2072183 SNP in NPC1L1 gene and its association with serum lipid profiles are different between the Mulao and Han populations. The difference in serum lipid profiles between the two ethnic groups might partly result from different rs2072183 SNP or NPC1L1 gene-environmental interactions.

Dataset Information

Association between the GPAM rs1129555 SNP and serum lipid profiles in the Maonan and Han populations.

Publications

Association between the <i>GPAM</i> rs1129555 SNP and serum lipid profiles in the Maonan and Han populations.

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