Dataset Information

Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children.

ABSTRACT: Biliary atresia (BA) is a devastating liver disease of complex pathogenesis in neonates, characterized by an inflammatory and fibrosing obstruction of extrahepatic bile ducts. Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is expressed on the surface of a subset of regulatory T cells (Treg) and down regulates the human immune response. To investigate the possible association between CTLA4 gene polymorphisms and BA susceptibility, we conducted a case-control study in the Chinese children. Three single nucleotide polymorphisms (SNPs) in the CLTA4 gene (rs231725, rs231775 and rs3087243) were genotyped in 113 BA patients and 133 healthy controls. The statistical analysis revealed no significant difference between BA patients and healthy controls in allele or genotype frequencies (rs231725, P = 0.2718, OR = 0.814, 95% CI = 0.564-1.175; rs231775, P = 0.1599, OR = 1.316, 95% CI = 0.897-1.931; rs3087243, P = 0.0572, OR = 1.582, 95% CI = 0.984-2.543), neither in the distribution of haplotypes of these CTLA4 gene SNPs. The result of our study is the first one to provide the evidence that there is no significant association between CLTA4 gene polymorphisms and BA susceptibility in Chinese children.

SUBMITTER: Liu J

PROVIDER: S-EPMC6958283 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children.

Liu Jia J Yang Yifan Y Dong Rui R Zheng Chao C Pei Jiahao J Chen Gong G Shen Zhen Z Huang Yanlei Y Zheng Shan S

International journal of clinical and experimental pathology 20180501 5

Biliary atresia (BA) is a devastating liver disease of complex pathogenesis in neonates, characterized by an inflammatory and fibrosing obstruction of extrahepatic bile ducts. Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is expressed on the surface of a subset of regulatory T cells (Treg) and down regulates the human immune response. To investigate the possible association between CTLA4 gene polymorphisms and BA susceptibility, we conducted a case-control study in the Chinese children. Th ...[more]

PMID: 31938405

Similar Datasets

Project description:Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma. To detect the association between LIN28B gene polymorphisms and hepatoblastoma risk in Chinese children, we conducted a five-center case-control study of 275 hepatoblastoma patients and 1018 cancer-free controls. Four potentially functional polymorphisms were genotyped using the Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. We found that the rs314276 C>A polymorphism (AA vs. CC: adjusted OR=2.05, 95% CI=1.36-3.10, P=0.0006; AA vs. CA/CC: adjusted OR=2.11, 95% CI=1.43-3.12, P=0.0002) and rs9404590 T>G (GG vs. TT: adjusted OR=1.89, 95% CI=1.20-3.00, P=0.007; GG vs. TT/TG: adjusted OR=1.87, 95% CI=1.20-2.92, P=0.006) were associated with increased hepatoblastoma risk. Combination analysis of risk genotypes showed that patients with four risk genotypes had a higher chance of developing hepatoblastoma than carriers of 1 to 3 risk genotypes. Stratification analysis showed the significant association between the rs314276 AA genotype and hepatoblastoma risk in both age and sex groups, as well as clinical stages III+IV cases. The rs9404590 GG genotype was associated with hepatoblastoma risk in participants' ≥17 months, in females, and for those with clinical stages III+IV disease. Furthermore, four risk genotypes confer higher hepatoblastoma susceptibility in both age and sex groups, as well as groups with clinical stages III+IV disease. Genotype-based gene expression analysis confirmed that the rs9404590 T>G polymorphism was significantly associated with altered LIN28B gene expression. We further validated our findings using false-positive probability analysis. This finding suggested that LIN28B gene polymorphisms may be associated with an increased predisposition to hepatoblastoma.

Dataset Information

Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children.

Publications

Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets