Ontology highlight
ABSTRACT:
SUBMITTER: Uechi T
PROVIDER: S-EPMC6958429 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Uechi Tamayo T Kenmochi Naoya N
Pharmaceuticals (Basel, Switzerland) 20191009 4
Diamond-Blackfan anemia (DBA) is a rare bone marrow failure syndrome characterized by red blood cell aplasia. Currently, mutations in 19 ribosomal protein genes have been identified in patients. However, the pathogenic mechanism of DBA remains unknown. Recently, several DBA models were generated in zebrafish (<i>Danio rerio</i>) to elucidate the molecular pathogenesis of disease and to explore novel treatments. Zebrafish have strong advantages in drug discovery due to their rapid development and ...[more]