Ontology highlight
ABSTRACT:
SUBMITTER: Su P
PROVIDER: S-EPMC6958791 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Su Peng P Ying Min M Han Zengpeng Z Xia Jinjin J Jin Sen S Li Yingli Y Wang Huadong H Xu Fuqiang F
Molecular brain 20200113 1
Neurotropic viral transsynaptic tracing is an increasingly powerful technique for dissecting the structure and function of neural circuits. Herpes simplex virus type 1 strain H129 has been widely used as an anterograde tracer. However, HSV tracers still have several shortcomings, including high toxicity, low sensitivity and non-specific retrograde labeling. Here, we aimed to construct high-brightness HSV anterograde tracers by increasing the expression of exogenous genes carried by H129 viruses. ...[more]