Dataset Information

The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population.

ABSTRACT: Long non-coding RNAs (LncRNA) have been wildly explored in several malignant tumors. This study aimed to evaluate the effect of HOXA11-AS polymorphisms (rs17427875 and rs11564004) on lung cancer susceptibility and its interaction with smoking exposure. This hospital-based case-control study, which included 466 cases and 557 controls, was carried out in Shenyang City, Liaoning province. The genotyping method was TaqMan allelic discrimination assay and all statistical analysis were performed by SPSS 20.0 and R (3.5.3). The results demonstrated that HOXA11AS-rs17427875 polymorphisms were correlated with the susceptibility of lung adenocarcinoma. T alleles of rs17427875 played a portal role in increasing lung adenocarcinoma risk. HOXA11AS-rs11564004 polymorphisms had the significant association with lung cancer risks, as well as its subtypes like non-small cell lung cancer, adenocarcinoma. The allele G of rs11564004 acted as a protective factor for lung cancer. The similar results were observed in the homozygous model and recessive model of rs11564004. Nevertheless, interaction analysis of the additive and multiplicative model scales showed no statistical significance between HOXA11-AS polymorphisms and smoking exposure in the development of lung cancer.

SUBMITTER: Gao M

PROVIDER: S-EPMC6959036 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population.

Gao Min M Li Hang H Bi Yanhong Y Zhang Ziwei Z Wang Shengli S Li Juan J Yang Zitai Z Lv Xiaoting X Zhou Baosen B Yin Zhihua Z

Journal of Cancer 20200101 3

Long non-coding RNAs (LncRNA) have been wildly explored in several malignant tumors. This study aimed to evaluate the effect of HOXA11-AS polymorphisms (rs17427875 and rs11564004) on lung cancer susceptibility and its interaction with smoking exposure. This hospital-based case-control study, which included 466 cases and 557 controls, was carried out in Shenyang City, Liaoning province. The genotyping method was TaqMan allelic discrimination assay and all statistical analysis were performed by SP ...[more]

PMID: 31942182

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Project description:Long noncoding RNAs (lncRNAs) are a new class of potential biomarkers and therapeutic targets for cancer. In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-PCAT1 (rs1026411 G>A, rs12543663?A>C, rs710886 T>C, and rs16901904 T>C) to investigate the association between genetic variant in lncRNA-PCAT1 and susceptibility to lung cancer. The study was a hospital-based case-control study including 561 cancer-free controls and 468 lung cancer cases. Genotyping of four SNPs was conducted by using Taqman® allelic discrimination methods. All statistical analyses were performed by using IBM SPSS Statistics 22 software. We failed to find significant associations between four SNPs and lung cancer risk in all models. However, polymorphisms in rs1026411 and rs710886 were observed to have significant associations with susceptibility to non-small cell lung cancer (AG vs. GG: odds ratio [OR]a?=?0.701, p*?=?0.020 and AA+AG vs. GG: ORa?=?0.711 [superscript "a" refers to OR adjusted by age, gender, and smoking], p*?=?0.017 [asterisks "*" refers to p adjusted by age, gender, and smoking] for rs1026411; CT vs. TT: ORa?=?0.723, p*?=?0.047 and CC+CT vs. TT: ORa?=?0.729, p*?=?0.038 for rs710886). Besides, the rs1026411 polymorphism had a similar association with lung adenocarcinoma risk (AG vs. GG: ORa?=?0.663, p*?=?0.019 and AA+AG vs. GG: ORa?=?0.685, p*?=?0.020). Polymorphisms in rs710886 and rs16901904 were observed to be associated with lung squamous cell carcinoma risk (CC+CT vs. TT: ORa?=?0.638, p*?=?0.040 for rs710886; CC vs. TT: ORa?=?2.582, p*?=?0.033 and CC vs. TT+CT: ORa?=?2.381, p*?=?0.048 for rs16901904). In addition, there were no significant results in gene-environmental interactions in both additive and multiplicative models. Our results suggested that polymorphisms in lncRNA-PCAT1 might be associated with lung cancer susceptibility in a northeastern Chinese population. The results of gene-environmental interactions were not significant in lung cancer.

Dataset Information

The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population.

Publications

The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population.

Similar Datasets

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