The somatic mutation landscape of Chinese Colorectal Cancer.
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ABSTRACT:
SUBMITTER: Ma R
PROVIDER: S-EPMC6959081 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The somatic mutation landscape of Chinese Colorectal Cancer.
Ma Rong R Jing Changwen C Zhang Yuan Y Cao Haixia H Liu Siwen S Wang Zhuo Z Chen Dan D Zhang Junying J Wu Yang Y Wu Jianzhong J Feng Jifeng J
Journal of Cancer 20200101 5
Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole exome-sequencing analysis of 63 CRC cases. We found that Chinese CRC were hypermutated, which were enriched in ECM-receptor interaction, antigen processing and presentation, and fo ...[more]
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