The Role of Toll-Like Receptors in the Production of Cytokines by Human Lung Macrophages.

ABSTRACT:

Background

The Toll-like receptor (TLR) family is involved in the recognition of and response to microbial infections. These receptors are expressed in leukocytes. TLR stimulation induces the production of proinflammatory cytokines and chemokines. Given that human lung macrophages (LMs) constitute the first line of defense against inhaled pathogens, the objective of this study was to investigate the expression and function of TLR subtypes in this cell population.

Methods

Human primary LMs were obtained from patients undergoing surgical resection. The RNA and protein expression levels of TLRs, chemokines, and cytokines were assessed after incubation with subtype-selective agonists.

Results

In human LMs, the TLR expression level varied from one subtype to another. Stimu

SUBMITTER: Grassin-Delyle S 

PROVIDER: S-EPMC6959095 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature