Ontology highlight
ABSTRACT:
SUBMITTER: Dai Y
PROVIDER: S-EPMC6959358 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dai Yuanyuan Y Amenov Asset A Ignatyeva Nadezda N Koschinski Andreas A Xu Hang H Soong Poh Loong PL Tiburcy Malte M Linke Wolfgang A WA Zaccolo Manuela M Hasenfuss Gerd G Zimmermann Wolfram-Hubertus WH Ebert Antje A
Scientific reports 20200114 1
The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein misalignment and impaired contractility. Yet it is not known how TnT mutation causes dysfunction of sarcomere microdomains and how these events contribu ...[more]