Dataset Information

Lifetime alcohol use among persons living with HIV is associated with frailty.

ABSTRACT:

Background

The average lifespan of persons living with HIV (PLWH) on antiretroviral therapy approximates the general population. However, PLWH are susceptible to early aging and frailty. Behaviors such as alcohol consumption may contribute to frailty among PLWH.

Objective

To determine the relationships between recent and lifetime alcohol use and frailty among PLWH.

Design

Cross-sectional, prospective cohort study of in-care PLWH (n?=?365) participating in the New Orleans Alcohol Use in HIV Study.

Methods

Recent alcohol exposure was measured by the 30-day alcohol timeline follow-back (TLFB) assessment and by whole-blood-spot phosphatidylethanol (PEth) quantitation. Lifetime alcohol exposure (LAE) was estimated by a modified lifetime drinking history instrument. Frailty was assessed by a 58-item deficit index (DI58) and the phenotypic frailty index (PFI). The Veterans Aging Cohort Study Risk Index 2.0 was calculated.

Results

Using generalized linear regression, LAE was positively associated with the DI58 (95% CI 0.001--0.006) and PFI severity (95% CI 0.004--0.023) after adjustment for age and other factors. Conversely, recent alcohol exposure was negatively associated with the DI58 [TLFB 95% CI: (-0.126 to -0.034), PEth: (-0.163 to -0.058)] and PFI severity [TLFB 95% CI (-0.404 to -0.015), PEth (-0.406 to 0.034)]. The VACS was not associated with alcohol use. Median per-decade alcohol exposure peaked in the second decade and tapered with aging thereafter. Increasing LAE and decreasing TLFB were co-associated with a specific subset of health deficits.

Conclusion

Lifetime alcohol use is positively associated with frailty among PLWH. Specific health deficits may discourage alcohol consumption in some PLWH.

SUBMITTER: Maffei VJ

PROVIDER: S-EPMC6960033 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Lifetime alcohol use among persons living with HIV is associated with frailty.

Maffei Vincent J VJ Ferguson Tekeda F TF Brashear Meghan M MM Mercante Donald E DE Theall Katherine P KP Siggins Robert W RW Taylor Christopher M CM Molina Patricia P Welsh David A DA

AIDS (London, England) 20200201 2

<h4>Background</h4>The average lifespan of persons living with HIV (PLWH) on antiretroviral therapy approximates the general population. However, PLWH are susceptible to early aging and frailty. Behaviors such as alcohol consumption may contribute to frailty among PLWH.<h4>Objective</h4>To determine the relationships between recent and lifetime alcohol use and frailty among PLWH.<h4>Design</h4>Cross-sectional, prospective cohort study of in-care PLWH (n = 365) participating in the New Orleans Al ...[more]

PMID: 31714352

Similar Datasets

Project description:BackgroundHazardous alcohol use is detrimental to persons with HIV (PWH), impacting medication adherence and liver function, yet globally resources to target alcohol use behavior in this population are limited. Few studies have identified the costs of integrating alcohol reduction interventions into HIV care.ObjectiveTo estimate the costs of implementing and delivering two evidence-based behavioral counseling interventions targeting hazardous alcohol use among persons with HIV and to estimate the costs of scale-up in ART clinics in Thai Nguyen, Vietnam.MethodsWe undertook a micro-costing approach to determine the costs of delivering two adapted evidence-based interventions to reduce alcohol use: an intensive combined cognitive behavioral therapy and motivational enhancement therapy-informed intervention (CoI) and an abbreviated brief alcohol intervention (BI). A total of 294 participants with hazardous alcohol use were identified through a brief screening tool and received the CoI (n = 147) and the BI (n = 147) over 3 months. We estimated costs using time and motion studies, budget analysis, staff interviews, and participant questionnaires. Data were collected from 2016 to 2018 in VND and converted to USD.ResultsThe total cost of implementation and administration of the intervention to 147 participants receiving the CoI was $13,900 ($95 per participant) and to 147 participants receiving the BI was $5700 ($39 per participant). Implementation and startup costs including training accounted for 27% of costs for the CoI and 28% for the BI. Counselor costs accounted for a large proportion of both the CoI (41%) and the BI (30%).ConclusionsImplementing and delivering alcohol reduction interventions to people with HIV in Vietnam with appropriate fidelity is costly. These costs may be reduced, particularly counselor labor costs, by using an evidence-based brief intervention format. Future research should explore the budgetary impact of brief and combined interventions to reduce hazardous alcohol use, particularly among vulnerable populations.

Dataset Information

Lifetime alcohol use among persons living with HIV is associated with frailty.

Background

Objective

Design

Methods

Results

Conclusion

Publications

Lifetime alcohol use among persons living with HIV is associated with frailty.

Similar Datasets

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