Ontology highlight
ABSTRACT:
SUBMITTER: Valero T
PROVIDER: S-EPMC6961122 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20191125 1
The search for novel targeted inhibitors active on glioblastoma multiforme is crucial to develop new treatments for this unmet clinical need. Herein, we report the results from a screening campaign against glioma cell lines using a proprietary library of 100 structurally-related pyrazolopyrimidines. Data analysis identified a family of compounds featuring a 2-amino-1,3-benzoxazole moiety (eCF309 to eCF334) for their antiproliferative properties in the nM range. These results were validated in pa ...[more]