Alcohol consumption is associated with reduced creatine levels in the hippocampus of older adults.
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ABSTRACT:
SUBMITTER: Demnitz N
PROVIDER: S-EPMC6961205 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Alcohol consumption is associated with reduced creatine levels in the hippocampus of older adults.
Demnitz Naiara N Topiwala Anya A Zsoldos Enikő E Stagg Charlotte J CJ Emir Uzay E UE Johansen-Berg Heidi H Ebmeier Klaus P KP Sexton Claire E CE
Psychiatry research. Neuroimaging 20191116
Besides its well established susceptibility to ageing, the hippocampus has also been shown to be affected by alcohol consumption. Proton spectroscopy (<sup>1</sup>H-MRS) of the hippocampus, particularly at high-field 7T MRI, may further our understanding of these associations. Here, we aimed to examine how hippocampal metabolites varied with age and alcohol consumption. Hippocampal metabolite spectra were acquired in 37 older adults using 7T <sup>1</sup>H-MRS, from which we determined the absolu ...[more]
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