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Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors.

ABSTRACT: BACKGROUND:Atherosclerotic cardiovascular (CV) events commonly occur in individuals with a low CV risk burden. This study evaluated the ability of the triglyceride glucose (TyG) index to predict subclinical coronary artery disease (CAD) in asymptomatic subjects without traditional CV risk factors (CVRFs). METHODS:This retrospective, cross-sectional, and observational study evaluated the association of TyG index with CAD in 1250 (52.8?±?6.5?years, 46.9% male) asymptomatic individuals without traditional CVRFs (defined as systolic/diastolic blood pressure???140/90?mmHg; fasting glucose ?126?mg/dL; total cholesterol ?240?mg/dL; low-density lipoprotein cholesterol ?160?mg/dL; high-density lipoprotein cholesterol

SUBMITTER: Park GM

PROVIDER: S-EPMC6961240 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors.

Park Gyung-Min GM Cho Young-Rak YR Won Ki-Bum KB Yang Yu Jin YJ Park Sangwoo S Ann Soe Hee SH Kim Yong-Giun YG Park Eun Ji EJ Kim Shin-Jae SJ Lee Sang-Gon SG Yang Dong Hyun DH Kang Joon-Won JW Lim Tae-Hwan TH Kim Hong-Kyu HK Choe Jaewon J Lee Seung-Whan SW Kim Young-Hak YH

Lipids in health and disease 20200114 1

<h4>Background</h4>Atherosclerotic cardiovascular (CV) events commonly occur in individuals with a low CV risk burden. This study evaluated the ability of the triglyceride glucose (TyG) index to predict subclinical coronary artery disease (CAD) in asymptomatic subjects without traditional CV risk factors (CVRFs).<h4>Methods</h4>This retrospective, cross-sectional, and observational study evaluated the association of TyG index with CAD in 1250 (52.8 ± 6.5 years, 46.9% male) asymptomatic individua ...[more]

PMID: 31937313

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Project description:BackgroundThe triglyceride-glucose (TyG) index has been proposed as a potential predictor of adverse prognosis of cardiovascular diseases (CVDs). However, its prognostic value in patients with coronary heart disease (CHD) and hypertension remains unclear.MethodsA total of 1467 hospitalized patients with CHD and hypertension from January 2021 to December 2021 were included in this prospective and observational clinical study. The TyG index was calculated as Ln [fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2]. Patients were divided into tertiles according to TyG index values. The primary endpoint was a compound endpoint, defined as the first occurrence of all-cause mortality or total nonfatal CVDs events within one-year follow up. The secondary endpoint was atherosclerotic CVD (ASCVD) events, including non-fatal stroke/transient ischemic attack (TIA) and recurrent CHD events. We used restricted cubic spline analysis and multivariate adjusted Cox proportional hazard models to investigate the associations of the TyG index with primary endpoint events.ResultsDuring the one-year follow-up period, 154 (10.5%) primary endpoint events were recorded, including 129 (8.8%) ASCVD events. After adjusting for confounding variables, for per standard deviation (SD) increase in the TyG index, the risk of incident primary endpoint events increased by 28% [hazard ratio (HR) = 1.28, 95% confidence interval (CI) 1.04-1.59]. Compared with subjects in the lowest tertile (T1), the fully adjusted HR for primary endpoint events was 1.43 (95% CI 0.90-2.26) in the middle (T2) and 1.73 (95% CI 1.06-2.82) in highest tertile (T3) (P for trend = 0.018). Similar results were observed in ASCVD events. Restricted cubic spline analysis also showed that the cumulative risk of primary endpoint events increased as TyG index increased.ConclusionsThe elevated TyG index was a potential marker of adverse prognosis in patients with CHD and hypertension.

Dataset Information

Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors.

Publications

Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors.

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