Dataset Information

Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015.

ABSTRACT: BackgroundPreviously a country with medium tuberculosis (TB) burden, Serbia almost reached a low TB burden during the period 2005 to 2015.AimThe aim of this study was to analyse the trends in notification rates and treatment success rates as well as to identify predictors of treatment outcomes.MethodsWe performed a trend analysis and logistic regression analysis of 17,441 TB cases registered from 2005 to 2015 in all health facilities in Serbia, to identify predictors of treatment success, loss to follow-up and mortality.ResultsFrom 2005 to 2015, TB notification rate and mortality in Serbia decreased but treatment success remained below the global target. Loss to follow-up was associated with retreatment (odds ratio (OR)?=?2.38; 95% confidence interval (CI):?2.08-2.77), male sex (OR?=?1.57; 95% CI:?1.39-1.79), age younger than 65 years (OR?=?1.37; 95% CI:?1.20-1.51), lower education level (OR?=?2.57; 95% CI:?1.74-3.80) and pulmonary TB (OR?=?1.28; 95% CI:?1.06-1.56). Deaths were more frequent in retreatment cases (OR?=?1.39; 95% CI:?1.12-1.61), male patients (OR?=?1.34; 95% CI:?1.19-1.52), those 65 years and older?(OR?=?4.34; 95% CI:?4.00-5.00), those with lower education level (OR?=?1.63; 95% CI:?1.14-2.33) and pulmonary TB (OR?=?2.24; 95% CI:?1.78-2.83).ConclusionsSpecial interventions should be implemented to address groups at risk of poor treatment outcome.

SUBMITTER: Stosic M

PROVIDER: S-EPMC6961260 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015.

Stosic Maja M Grujicic Sandra Sipetic SS Grgurevic Anita A Kuruc Vesna V Ristic Lidija L Antonijevic Gordana G Jevtic Miroslav M Plavsa Dragana D Vukicevic Tatjana Adzic TA

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20200101 1

BackgroundPreviously a country with medium tuberculosis (TB) burden, Serbia almost reached a low TB burden during the period 2005 to 2015.AimThe aim of this study was to analyse the trends in notification rates and treatment success rates as well as to identify predictors of treatment outcomes.MethodsWe performed a trend analysis and logistic regression analysis of 17,441 TB cases registered from 2005 to 2015 in all health facilities in Serbia, to identify predictors of treatment success, loss t ...[more]

PMID: 31937395

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Project description:BackgroundSeverity of TB increases in refugee populations. Monitoring TB case notification and treatment outcomes are essential to improve the effectiveness of TB programs. This study aimed to investigate trends in TB case notification and treatment outcomes and explore factors associated with unsuccessful treatment outcome in refugee camps in Ethiopia.MethodsIn this retrospective cohort study, demographic and clinical data of all TB cases registered in 25 refugee camps in Ethiopia from January 2014 to December 2017 were extracted. Multivariate logistic regression was fitted to estimate odds ratios and corresponding 95% confidence intervals for the measure of association linked with factors significantly associated with unsuccessful treatment outcomes.ResultsA total of 1553 TB cases, mean age 27.7 years, were registered from 2014 to 2017. Of these notified cases 54.7% were men, 27.7% children (< 15 years), 71.2% pulmonary TB (PTB), 27.8% Extra-PTB (EPTB) and 98.3% new and relapse. From 2014 to 2017: there was consistent increase in number of notified TB cases (138 to 588 cases), in percentage of EPTB (23.2 to 32.7%), in contribution of children to total TB cases (18.8 to 30.1%) and to EPTB (40.6 to 65.1%), and in proportion of bacteriologically confirmed new and relapse pulmonary cases (43.8 to 64.8%). Treatment success rates for all TB cases remained lower at 72.7-79.4%. On average 24.8% had unfavorable treatment outcome, including 11.5% not evaluated, 8.0% LTFU, 4.8% died and 0.5% treatment failed. Unsuccessful treatment was significantly associated with pretreatment weight below 40 Kg, age over 45 years, and being HIV positive.ConclusionsThere was continuous increase in notified TB cases and in percentage of childhood TB. Proportion of bacteriologically confirmed new and relapse pulmonary cases increased overtime. TB treatment success remained lower than the national achievement in 2017 (96%) and global target (> = 90%), which needs improvement. The higher LTFU, not evaluated, and death suggests the need to strengthen adherence education and supervision. Special socio-economic support and monitoring is required for patients with pretreatment weight below 40 Kg, age over 45 years and HIV positives.

Dataset Information

Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015.

Publications

Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015.

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