Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress.

ABSTRACT:

Background

Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, a member of the vitamin B complex, in considered to be strongly associated with the function and development of the central nervous system. Thus, in this study, we established a model of depression through chronic unpredictable mild stress (CUMS) in rats and assessed the antidepressant effects and mechanisms of folic acid.

Methods

Sprague-Dawley rats were randomly divided into four groups: control, chronic unpredictable mild stress (CUMS), CUMS treated with folic acid, and CUMS treated with citalopram. Rats were assessed in terms of weight change, open-field test and sucrose preference. Homocysteine, monoamine neurotransmitters, interleukin-6, brain-derived neurotrophic factor (BDNF), ?-endorphin levels in the serum and brains of rats were analysed.

Results

Folic acid exhibited antidepressant-like effects in open-field and sucrose preference tests. Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and ?-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration.

Conclusions

These findings serve as preclinical evidence that folic acid plays an antidepressant-like role in several pathways involving monoamine neurotransmitters. Thus, folic acid may be used as a potential antidepressant.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6961331 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature