Ontology highlight
ABSTRACT:
SUBMITTER: Enyindah-Asonye G
PROVIDER: S-EPMC6961594 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Enyindah-Asonye Gospel G Nwankwo Anthony A Rahman Mohammad Arif MA Hunegnaw Ruth R Hogge Christopher C Helmold Hait Sabrina S Ko Eun-Ju EJ Hoang Tanya T Robert-Guroff Marjorie M
Frontiers in immunology 20200108
Effective CD8<sup>+</sup> T-cell responses play an important role in determining the course of SIV/HIV viral infection. Here we identified a unique population of dysfunctional CD8<sup>+</sup> T-cells in lymphoid tissues and bronchoalveolar lavage (BAL) of rhesus macaques with chronic SIV infection characterized by co-expression of CD6 and PD-1. The frequency of CD6 and PD-1 co-expressing CD8<sup>+</sup> T-cells was significantly increased in lymphoid tissues and BAL during chronic SIV infection ...[more]