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MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer.


ABSTRACT: Background:Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer. hsa-miR-195 has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) in a previous study. However, the diagnostic value of hsa-miR-195-5p in lung cancer has not been investigated. Methods:To evaluate the ability of hsa-miR-195-5p to diagnose lung cancer, we compared the expression of hsa-miR-195-5p in lung cancer patients, COPD patients, and normal controls. Receiver operating characteristic (ROC) curve analysis was performed to investigate the sensitivity and specificity of hsa-miR-195-5p. Coexpression network and pathway analysis were carried out to explore the mechanism. Results:We found that hsa-miR-195-5p had lower expression in lung cancer and COPD patients than in normal controls, and the AUC was 0.92 for diagnosing lung cancer. hsa-miR-143 correlated with hsa-miR-195-5p, and by combining these two microRNAs, the AUC was 0.97 for diagnosing lung cancer. Conclusions:hsa-miR-195-5p may act as a biomarker that contributes to the diagnosis of lung cancer and the detection of its high-risk population.

SUBMITTER: Li L 

PROVIDER: S-EPMC6961786 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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MicroRNA Biomarker <i>hsa-miR-195-5p</i> for Detecting the Risk of Lung Cancer.

Li Lei L   Feng Tienan T   Zhang Weituo W   Gao Sumeng S   Wang Ruoyang R   Lv Wenwen W   Zhu Tengteng T   Yu Herbert H   Qian Biyun B  

International journal of genomics 20200102


<h4>Background</h4>Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer. <i>hsa-miR-195</i> has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) in a previous study. However, the diagnostic value of <i>hsa-miR-195-5p</i> in lung cancer has not been investigated.<h4>Methods</h4>To evaluate the ability of <i>hsa-miR-195-5p</i> to diagnose lung cancer, we compared the expression of <i>hsa-miR-  ...[more]

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