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Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation.

ABSTRACT: Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin. Pepsin positivity is associated with nodal involvement, suggesting that pepsin may have a role in metastasis. Treatment of FaDu cancer cells with pepsin increased cell proliferation, possibly by inducing G1/S transition. We also observed significant changes in expression of genes involved in NF-kappaB, TRAIL and Notch signaling. Our data suggest that pepsin plays an important role in HPSCC and that targeting pepsin could have potential therapeutic benefits.

SUBMITTER: Niu K

PROVIDER: S-EPMC6961942 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation.

Niu Kai K Guo Chunjie C Teng Shiyong S Zhou Dandan D Yu Shuyuan S Yin Wanzhong W Wang Ping P Zhu Wei W Duan Maoli M

PloS one 20200115 1

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin. Pepsin positivity is associated with nodal involvement, suggesting that pepsin may have a ro ...[more]

PMID: 31940393

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Dataset Information

Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation.

Publications

Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation.

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