Ontology highlight
ABSTRACT:
SUBMITTER: Ahfeldt T
PROVIDER: S-EPMC6962705 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Stem cell reports 20200102 1
Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes results in the relatively selective death of nigral dopaminergic neurons (DNs). To address this question, we modeled PD by knocking out the PD genes PARKIN (PRKN), DJ-1 (PARK7), and ATP13A2 (PARK9) in independent isogenic human pluripotent stem cell (hPSC) lines. We found ...[more]