Slit3 regulates migration of endothelial progenitor cells by activation of the RhoA/Rho kinase pathway.
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ABSTRACT:
SUBMITTER: Dou C
PROVIDER: S-EPMC6962882 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Slit3 regulates migration of endothelial progenitor cells by activation of the RhoA/Rho kinase pathway.
Dou Chunjiang C Wang Haixia H Zhou Gang G Zhu Hai H Wen Huazhi H Xu Shengkai S
International journal of clinical and experimental pathology 20180701 7
Nerves and blood vessels are in close proximity, indicating possible biomolecular interactions. Slit/Robo signaling pathways play critical roles in cell proliferation and motility. Endothelial progenitor cells (EPCs) participate in angiogenesis and vascular homeostasis. EPC migration induced by Slit3 has not been fully characterized. Thus, the expression of Slit and Robo in EPCs was examined, and the chemotactic functions of Slit3 and the Slit/Robo signaling pathway regulatory mechanisms were ex ...[more]
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