Ontology highlight
ABSTRACT:
SUBMITTER: Fochi S
PROVIDER: S-EPMC6963194 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Fochi Stefania S Ciminale Vincenzo V Trabetti Elisabetta E Bertazzoni Umberto U D'Agostino Donna M DM Zipeto Donato D Romanelli Maria Grazia MG
Pathogens (Basel, Switzerland) 20191210 4
The risk of developing adult T-cell leukemia/lymphoma (ATLL) in individuals infected with human T-cell lymphotropic virus 1 (HTLV-1) is about 3-5%. The mechanisms by which the virus triggers this aggressive cancer are still an area of intensive investigation. The viral protein Tax-1, together with additional regulatory proteins, in particular HTLV-1 basic leucine zipper factor (HBZ), are recognized as relevant viral factors required for both viral replication and transformation of infected cells ...[more]