Ontology highlight
ABSTRACT:
SUBMITTER: Snow JA
PROVIDER: S-EPMC6963835 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Snow Jazmine A JA Murthy Vaibhav V Dacus Dalton D Hu Changkun C Wallace Nicholas A NA
Pathogens (Basel, Switzerland) 20191126 4
Given the high prevalence of cutaneous genus beta human papillomavirus (β-HPV) infections, it is important to understand how they manipulate their host cells. This is particularly true for cellular responses to UV damage, since our skin is continually exposed to UV. The E6 protein from β-genus HPV (β-HPV E6) decreases the abundance of two essential UV-repair kinases (ATM and ATR). Although β-HPV E6 reduces their availability, the impact on downstream signaling events is unclear. We demonstrate t ...[more]