Genetic Basis and Physiological Effects of Lipid A Hydroxylation in Pseudomonas aeruginosa PAO1.
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ABSTRACT:
SUBMITTER: Lo Sciuto A
PROVIDER: S-EPMC6963906 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Genetic Basis and Physiological Effects of Lipid A Hydroxylation in <i>Pseudomonas aeruginosa</i> PAO1.
Lo Sciuto Alessandra A Cervoni Matteo M Stefanelli Roberta R Spinnato Maria Concetta MC Di Giamberardino Alessandra A Mancone Carmine C Imperi Francesco F
Pathogens (Basel, Switzerland) 20191210 4
Modifications of the lipid A moiety of lipopolysaccharide influence the physicochemical properties of the outer membrane of Gram-negative bacteria. Some bacteria produce lipid A with a single hydroxylated secondary acyl chain. This hydroxylation is catalyzed by the dioxygenase LpxO, and is important for resistance to cationic antimicrobial peptides (e.g., polymyxins), survival in human blood, and pathogenicity in animal models. The lipid A of the human pathogen <i>Pseudomonas aeruginosa</i> can ...[more]
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