Ontology highlight
ABSTRACT:
SUBMITTER: Vasina DV
PROVIDER: S-EPMC6963980 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Vasina Daria V DV Kleymenov Denis A DA Manuylov Victor A VA Mazunina Elena P EP Koptev Egor Yu EY Tukhovskaya Elena A EA Murashev Arkady N AN Gintsburg Alexander L AL Gushchin Vladimir A VA Tkachuk Artem P AP
Vaccines 20191101 4
Tuberculosis is known to be the biggest global health problem, causing the most deaths by a single infectious agent. Vaccine-development efforts are extremely important. This paper represents the results of the first-in-human trial of recombinant subunit tuberculosis vaccine GamTBvac in a Phase I study. GamTBvac is a new BCG booster candidate vaccine containing dextran-binding domain modified Ag85a and ESAT6-CFP10 MTB antigens and CpG ODN adjuvant, formulated with dextrans. Safety and immunogeni ...[more]