Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.
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ABSTRACT:
SUBMITTER: Sakurai T
PROVIDER: S-EPMC6964040 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.
Sakurai Toshiharu T Nishiyama Hiroki H Nagai Tomoyuki T Goto Susumu S Ogata Hiroyuki H Kudo Masatoshi M
BMC gastroenterology 20200115 1
<h4>Background</h4>Gankyrin (GK) is an oncoprotein which regulates inflammatory responses and its inhibition is considered as a possible anti-inflammatory therapy for inflammatory bowel disease (IBD).<h4>Methods</h4>In this study, we investigated the role of GK in epithelial cells using mice with intestinal epithelial cell-specific GK deletion in (i) the entire small intestine and colon (Villin-Cre;Gankyrin<sup>f/f</sup>) and (ii) the distal intestine and colon (Cdx2-Cre;Gankyrin<sup>f/f</sup>). ...[more]
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