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Associations between ethnicity, social contact, and pneumococcal carriage three years post-PCV10 in Fiji.


ABSTRACT: BACKGROUND:Pneumococcal carriage is a prerequisite for pneumococcal disease. Little is known about whether social contact frequency and intensity are associated with pneumococcal carriage. In Fiji, indigenous iTaukei have higher prevalence of pneumococcal carriage compared with Fijians of Indian Descent (FID). We hypothesised that contact differences may contribute to ethnic differences in pneumococcal carriage prevalence and density. METHODS:In 2015, young infants (5-8?weeks), toddlers (12-23?months), children (2-6?years), and caregivers from Suva and surrounding areas, participated in a cross-sectional survey (n?=?2014), three years post pneumococcal conjugate vaccine introduction. Demographic and contact data, and nasopharyngeal swabs were collected. Pneumococci were detected, and quantified using quantitative real-time PCR, with molecular serotyping by microarray. Associations between ethnicity, contact, and pneumococcal carriage and density were estimated using multivariable generalised estimating equation regression models. RESULTS:iTaukei participants had larger household sizes, higher pneumococcal carriage rates, more contacts, and more frequent contacts of longer duration, compared with FID. The odds of vaccine-type carriage increased by 28% (95% CI 8-53%) P?

SUBMITTER: Neal EFG 

PROVIDER: S-EPMC6964150 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Pneumococcal carriage is a prerequisite for pneumococcal disease. Little is known about whether social contact frequency and intensity are associated with pneumococcal carriage. In Fiji, indigenous iTaukei have higher prevalence of pneumococcal carriage compared with Fijians of Indian Descent (FID). We hypothesised that contact differences may contribute to ethnic differences in pneumococcal carriage prevalence and density.<h4>Methods</h4>In 2015, young infants (5-8 weeks), to  ...[more]

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