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Risk factors and clinical significance of elevated mitral valve gradient following valve repair for degenerative disease.


ABSTRACT:

Objectives

The risk factors and clinical effect of elevated mitral valve (MV) gradients after valve repair for degenerative valve disease remain insufficiently understood.

Methods

Between January 2004 and December 2015, a total of 484 patients underwent valve repair for degenerative disease. A true-sized full annuloplasty ring was implanted in all cases. We analysed the effect of preoperative and intraoperative factors on the postrepair gradient. Additionally, we explored the effect of postrepair gradients on long-term outcomes.

Results

On linear regression analysis, postrepair MV gradients were associated with patient age (coefficient?=?-0.110, standard error?=?0.005, P?=?0.034), body surface area (coefficient?=?0.905, standard error?=?0.340, P?=?0.008), implanted annuloplasty ring size (coefficient?=?-0.181, standard error?=?0.018, P?ConclusionsFollowing valve repair for degenerative MV disease, elevated gradients occur even when true-sized annuloplasty is performed. The late clinical results of valve repair with elevated postrepair gradient are impaired and further studies are needed to explore preventive measures aimed at resolving the issue.

SUBMITTER: Tomsic A 

PROVIDER: S-EPMC6964229 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Risk factors and clinical significance of elevated mitral valve gradient following valve repair for degenerative disease.

Tomšič Anton A   Hiemstra Yasmine L YL   Arabkhani Bardia B   Mertens Bart J A BJA   van Brakel Thomas J TJ   Versteegh Michel I M MIM   Marsan Nina Ajmone NA   Klautz Robert J M RJM   Palmen Meindert M  

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20200201 2


<h4>Objectives</h4>The risk factors and clinical effect of elevated mitral valve (MV) gradients after valve repair for degenerative valve disease remain insufficiently understood.<h4>Methods</h4>Between January 2004 and December 2015, a total of 484 patients underwent valve repair for degenerative disease. A true-sized full annuloplasty ring was implanted in all cases. We analysed the effect of preoperative and intraoperative factors on the postrepair gradient. Additionally, we explored the effe  ...[more]

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