Spinal signalling of C-fiber mediated pleasant touch in humans.
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ABSTRACT:
SUBMITTER: Marshall AG
PROVIDER: S-EPMC6964968 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Spinal signalling of C-fiber mediated pleasant touch in humans.
Marshall Andrew G AG Sharma Manohar L ML Marley Kate K Olausson Hakan H McGlone Francis P FP
eLife 20191224
C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integr ...[more]
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