Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles.
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ABSTRACT:
SUBMITTER: Guardia GDA
PROVIDER: S-EPMC6965107 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles.
Guardia Gabriela D A GDA Correa Bruna R BR Araujo Patricia Rosa PR Qiao Mei M Burns Suzanne S Penalva Luiz O F LOF Galante Pedro A F PAF
NPJ genomic medicine 20200116
Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization of GSCs is needed to develop more effective therapies. We conducted a study to identify differences in the splicing profile and expression of long non-coding RNAs in proneural and mesenchymal GSC cell lines. Genes related to cell cycle, DNA repair, cilium assembly, and splicing showed the most differences between GSC subgroups. We also ide ...[more]
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