Ontology highlight
ABSTRACT:
SUBMITTER: Xiong C
PROVIDER: S-EPMC6965176 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Xiong Chiyi C Wen Yunfei Y Zhao Jun J Yin Dengke D Xu Lingyun L Chelariu-Raicu Anca A Yao Cody C Leng Xiaohong X Liu Jinsong J Chaudhari Rajan R RR Zhang Shuxing S Sood Anil K AK Li Chun C
Scientific reports 20200116 1
The tyrosine kinase receptor EphB4 is frequently overexpressed in ovarian and other solid tumors and is involved in interactions between tumor cells and the tumor microenvironment, contributing to metastasis. Trans-interaction between EphB4 and its membrane-bound ligand ephrin B2 (EFNB2) mediates bi-directional signaling: forward EFNB2-to-EphB4 signaling suppresses tumor cell proliferation, while reverse EphB4-to-EFNB2 signaling stimulates the invasive and angiogenic properties of endothelial ce ...[more]