Dataset Information

Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

ABSTRACT: BACKGROUND:Generalized gingival fibromatosis is characterized by a progressive overgrowth of the gingiva, which can be caused by a variety of factors. According to these factors, it can be defined as hereditary gingival fibromatosis, non-familial gingival fibromatosis or drug-induced gingival fibromatosis. Non-familial gingival fibromatosis is a rare entity that needs to be documented. CASE PRESENTATION:Here, we describe two cases of Chinese non-familial gingival fibromatosis. A six-year-old girl and a five-year-old boy presented with generalized gingival overgrowth. Clinical appearance, histological examination, and family history lead to the diagnosis of non-familial gingival fibromatosis. Real time PCR was performed to examine the expression of the ?2-integrin gene, ITGA2, and identified decreased expression of ITGA2 in the gingiva of patients compared to both their parents and healthy volunteers. This is the first evidence that suggests a role for ITGA2 in non-familial gingival fibromatosis. CONCLUSION:Our findings provide evidence that altered cell-matrix interactions via collagen receptors, such as ?2-integrin, may play a role in non-familial gingival fibromatosis. Thus, targeting collagen receptors might be an attractive target for the treatment of gingival fibromatosis.

SUBMITTER: Liu C

PROVIDER: S-EPMC6965286 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

Liu Chengcheng C Tao Tingting T Zhao Lei L Ding Yi Y

International journal of clinical and experimental pathology 20170701 7

<h4>Background</h4>Generalized gingival fibromatosis is characterized by a progressive overgrowth of the gingiva, which can be caused by a variety of factors. According to these factors, it can be defined as hereditary gingival fibromatosis, non-familial gingival fibromatosis or drug-induced gingival fibromatosis. Non-familial gingival fibromatosis is a rare entity that needs to be documented.<h4>Case presentation</h4>Here, we describe two cases of Chinese non-familial gingival fibromatosis. A s ...[more]

PMID: 31966593

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Project description:Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of pseudopockets and plaque accumulation. It affects both genders equally. Hereditary, drug-induced, and idiopathic gingival overgrowth have been reported. Hereditary gingival fibromatosis can occur as an isolated condition or as part of a genetic syndrome. The pathologic manifestation of gingival fibromatosis comprises excessive accumulation of extracellular matrix proteins, of which collagen type I is the most prominent example. Mutation in the Son-of-Sevenless-1 gene has been suggested as one possible etiological cause of isolated (non-syndromic) hereditary gingival fibromatosis, but mutations in other genes are also likely to be involved, given the heterogeneity of this condition. The most attractive concept of mechanism for drug-induced gingival overgrowth is epithelial-to-mesenchymal transition, a process in which interactions between gingival cells and the extracellular matrix are weakened as epithelial cells transdifferentiate into fibrogenic fibroblast-like cells. The diagnosis is mainly made on the basis of the patient's history and clinical features, and on histopathological evaluation of affected gingiva. Early diagnosis is important, mostly to exclude oral malignancy. Differential diagnosis comprises all pathologies in the mouth with excessive gingival overgrowth. Hereditary gingival fibromatosis may present as an autosomal-dominant or less commonly autosomal-recessive mode of inheritance. If a systemic disease or syndrome is suspected, the patient is directed to a geneticist for additional clinical examination and specialized diagnostic tests. Treatments vary according to the type of overgrowth and the extent of disease progression, thus, scaling of teeth is sufficient in mild cases, while in severe cases surgical intervention is required. Prognosis is precarious and the risk of recurrence exists.

Dataset Information

Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

Publications

Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

Similar Datasets

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