Sodium-Glucose Co-Transporter 2 Inhibitors and Fracture Risk.
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ABSTRACT:
SUBMITTER: Erythropoulou-Kaltsidou A
PROVIDER: S-EPMC6965547 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Sodium-Glucose Co-Transporter 2 Inhibitors and Fracture Risk.
Erythropoulou-Kaltsidou Anastasia A Polychronopoulos Georgios G Tziomalos Konstantinos K
Diabetes therapy : research, treatment and education of diabetes and related disorders 20191116 1
Patients with type 2 diabetes mellitus (T2DM) appear to have increased risk for fractures. In this context, the finding that canagliflozin, a sodium-glucose co-transporter-2 (SGLT) inhibitor, increased the risk for fracture compared with placebo in the Canagliflozin Cardiovascular Assessment Study (CANVAS), a large randomized controlled trial (RCT) in patients with established cardiovascular disease or multiple cardiovascular risk factors, created concern. In the present review, we summarize the ...[more]
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