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Programmed death ligand 1 expression in bladder rhabdomyosarcoma and its association with clinicopathological features.


ABSTRACT: The aim of this study was to detect PD-L1 expression in bladder rhabdomyosarcoma and its association with clinicopathological features and patient prognosis. PD-L1 expression was detected in paraffin-embedded sections obtained from 34 patients with bladder rhabdomyosarcoma via immunohistochemistry. Immunohistochemistry results were statistically analyzed to determine their association with patient clinicopathological features and survival outcomes. PD-L1-positive staining was observed in 47.1% (16/34) of patients. Metastatic tumor cells in the lymph nodes of two patients were positive for PD-L1 expression. PD-L1 expression was significantly different with regard to muscularis invasion, but the expression did not affect patient survival outcomes. We confirmed PD-L1 expression in bladder rhabdomyosarcoma, suggesting that PD-1/PD-L1 inhibitors are potential therapeutic agents for patients with bladder rhabdomyosarcoma.

SUBMITTER: Zhou P 

PROVIDER: S-EPMC6965761 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Programmed death ligand 1 expression in bladder rhabdomyosarcoma and its association with clinicopathological features.

Zhou Peng P   Wang Qiongren Q   Wang Chongshan C   Li Xiezhao X   Du Wei W   Liu Chunxiao C   Watanabe Masami M   Huang Peng P   Xu Abai A  

International journal of clinical and experimental pathology 20171001 10


The aim of this study was to detect PD-L1 expression in bladder rhabdomyosarcoma and its association with clinicopathological features and patient prognosis. PD-L1 expression was detected in paraffin-embedded sections obtained from 34 patients with bladder rhabdomyosarcoma via immunohistochemistry. Immunohistochemistry results were statistically analyzed to determine their association with patient clinicopathological features and survival outcomes. PD-L1-positive staining was observed in 47.1% (  ...[more]

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