Ontology highlight
ABSTRACT:
SUBMITTER: Jin JY
PROVIDER: S-EPMC6965825 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Jin Jie-Yuan JY Wu Pan-Feng PF Fan Liang-Liang LL Yu Fang F Li Jing-Jing JJ Fan Xue-Feng XF Huang Hao H Zeng Lei L Tang Ju-Yu JY Xiang Rong R
International journal of clinical and experimental pathology 20171101 11
<h4>Background</h4>Distal arthrogryposis (DA) is the most common congenital limb malformation secondary to the functional defects of joints and muscles. DA1 is one of the most commonly described forms of DA. The characteristics of DA1 include bilateral and symmetric clenched fist, overlapping fingers, camptodactyly, ulnar deviation of fingers, and positional foot deformities such as talipes equinovarus. Previous studies demonstrate that mutations of <i>TPM2, TNNI2, TNNT3, MYH3</i> and <i>MYBPC1< ...[more]