Dataset Information

Association between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk.

ABSTRACT: Glutathione peroxidase (GPX), one of the antioxidant enzymes, exerts a vital role in reducing oxidative damage. GPX1 Pro198Leu (rs1050450) polymorphism has been reported in the development of several cancers, while the results were inconsistent. We thus conducted this meta-analysis to identify the association between GPX1 (rs1050450) polymorphism and cancer risk. 52 eligible publications with 60 case-control studies were included, with 21,296 cancer patients and 30,346 controls. The results in total population suggested there was a significant association between GPX1 (rs1050450) polymorphism and cancer susceptibility in part genetic models (TT vs CT+CC: OR = 1.15, 95% CI = 1.01-1.32, P = 0.042; TT vs CC: OR = 1.15, 95% CI = 1.00-1.31, P = 0.044; T vs C: OR = 1.09, 95% CI = 1.01-1.17, P = 0.02). The stratified analysis by cancer types suggested a positive correlation between GPX1 (rs1050450) polymorphism and the development of bladder cancer (TT+CT vs CC: OR = 1.72, 95% CI = 1.09-2.70, P = 0.019; TT vs CT+CC: OR = 3.56, 95% CI = 1.42-8.94, P = 0.007; TT vs CC: OR = 3.75, 95% CI = 1.41-9.94, P = 0.008; T vs C: OR = 1.941, 95% CI = 1.17-3.22, P = 0.01) as well as head and neck cancer (TT vs CT+CC: OR = 2.19, 95% CI = 1.39-3.46, P = 0.001) and brain cancer (TT+CT vs CC: OR = 1.19, 95% CI = 1.03-1.37, P = 0.018). These results support that GPX1 (rs1050450) polymorphism might be a candidate marker for cancer risk with type-specific effects.

SUBMITTER: Wang C

PROVIDER: S-EPMC6965984 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Association between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk.

Wang Chengdi C Zhang Rui R Chen Nan N Yang Lan L Wang Yinsu Y Sun Yan Y Huang Lin L Zhu Min M Ji Yulin Y Li Weimin W

International journal of clinical and experimental pathology 20170901 9

Glutathione peroxidase (GPX), one of the antioxidant enzymes, exerts a vital role in reducing oxidative damage. GPX1 Pro198Leu (rs1050450) polymorphism has been reported in the development of several cancers, while the results were inconsistent. We thus conducted this meta-analysis to identify the association between GPX1 (rs1050450) polymorphism and cancer risk. 52 eligible publications with 60 case-control studies were included, with 21,296 cancer patients and 30,346 controls. The results in t ...[more]

PMID: 31966829

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Project description:Background and Objectives: Oxidative stress induced by increased reactive oxygen species (ROS) production plays an important role in carcinogenesis. The entire urinary tract is continuously exposed to numerous potentially mutagenic environmental agents which generate ROS during their biotransformation. In first line defense against free radicals, antioxidant enzymes superoxide dismutase (SOD2) and glutathione peroxidase (GPX1) both have essential roles. Altered enzyme activity and decreased ability of neutralizing free oxygen radicals as a consequence of genetic polymorphisms in genes encoding these two enzymes are well described so far. This study aimed to investigate the association of GPX1 (rs1050450) and SOD2 (rs4880) genetic variants with the urothelial bladder cancer (UBC) risk independently and in combination with smoking. Furthermore, we aimed to determine whether the UBC stage and pathological grade were influenced by GPX1 and SOD2 polymorphisms. Material and Methods: The study population included 330 patients with UBC (mean age 65 ± 10.3 years) and 227 respective controls (mean age 63.4 ± 7.9 years). Single nucleotide polymorphism (SNP) of GPX1 (rs1050450) was analyzed using the PCR-RFLP, while SOD2 (rs4880) SNP was analyzed using the q-PCR method. Results: Our results showed that UBC risk was significantly increased among carriers of at least one variant SOD2 Val allele compared to the SOD2 Ala16Ala homozygotes (OR = 1.55, p = 0.03). Moreover, this risk was even more pronounced in smokers with at least one variant SOD2 Val allele, since they have even 7.5 fold higher UBC risk (OR = 7.5, p < 0.001). Considering GPX1 polymorphism, we have not found an association with UBC risk. However, GPX1 genotypes distribution differed significantly according to the tumor stage (p ˂ 0.049) and pathohistological grade (p ˂ 0.018). Conclusion: We found that SOD2 genetic polymorphism is associated with the risk of UBC development independently and in combination with cigarette smoking. Furthermore, we showed that GPX1 genetic polymorphism is associated with the aggressiveness of the disease.

Dataset Information

Association between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk.

Publications

Association between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk.

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