Dataset Information

MMP-2 and MMP-9 gene polymorphisms associated with cervical cancer risk.

ABSTRACT: AIM:To inquire into whether there is any relationship between MMP-2 rs2285053 and MMP-9 rs3918242 polymorphisms and the onset risk of cervical cancer (CC) and invasion and metastasis. METHODS:Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was utilized to examine the frequency and distribution of MMP-2 rs2285053 and MMP-9 rs3918242 polymorphisms in 150 CC patients and 120 healthy individuals who were matched therewith in age and gender, and the CC risk and invasion and metastasis condition of individuals carrying different genotypes of the two single nucleotide polymorphisms (SNPs) were compared. The data were processed by SPSS 18.0 software. RESULTS:The differences of genotype distribution frequencies of the two SNPs between the two groups were not apparent (P > 0.05), and no significant relevance was found between the two SNPs and the lymphatic metastasis of CC. The CC risk for those carrying CC/TT (rs2285053) and CT/TT (rs3918242), CC (rs2285053) and CC (rs3918242), and CC (rs2285053) and CT/TT (rs3918242) respectively was 0.135, 1.138, and 1.182 times as much as that for those carrying CT/TT (rs2285053) and CC (rs3918242) (95% CI=0.028-0.660; 95% CI=0.615-2.103; 95% CI=0.558-2.502), reflecting that the two SNPs had interactions there between. CONCLUSIONS:MMP-2 rs2285053 and MMP-9 rs3918242 polymorphisms may have correlations with CC susceptibility.

SUBMITTER: Zhang H

PROVIDER: S-EPMC6966040 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

<i>MMP-2</i> and <i>MMP-9</i> gene polymorphisms associated with cervical cancer risk.

Zhang Haiyan H Li Guang G Zhang Zhen Z Wang Surong S Zhang Shiqian S

International journal of clinical and experimental pathology 20171201 12

<h4>Aim</h4>To inquire into whether there is any relationship between <i>MMP-2</i> rs2285053 and <i>MMP-9</i> rs3918242 polymorphisms and the onset risk of cervical cancer (CC) and invasion and metastasis.<h4>Methods</h4>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was utilized to examine the frequency and distribution of <i>MMP-2</i> rs2285053 and <i>MMP-9</i> rs3918242 polymorphisms in 150 CC patients and 120 healthy individuals who were matched therewit ...[more]

PMID: 31966538

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Project description:ObjectivesStudies have suggested that polymorphisms in genes involved in immune recognition and antigen presentation are associated with cervical cancer risk. We sought to replicate a recent study which reported an association between specific SNPs on CD83 and cervical cancer and to further explore whether effects varied by age, clinical stage (in situ versus invasive), and histology (squamous carcinomas versus adenocarcinomas).MethodsWe evaluated the association between SNPs on CD83 and cervical cancer in a multicenter case-control study of cervical cancer conducted in the Eastern United States (263 cases, 307 controls), focusing on the five SNPs (RS9296925, RS853360, RS9230, RS9370729, RS750749) previously found to be associated with cervical cancer. We also pooled data from the Eastern U.S. (263 cases) with those from the original report (377 cases) to assess the effects of CD83 on the age at diagnosis, disease stage, and histology. Risk estimates (ORs) and 95% confidence intervals were estimated using logistic regression; trend tests were performed under an additive model.ResultsConsistent with the original report, carriers of the CT or CC genotypes for one of the five CD83 SNPs evaluated (rs750749) demonstrated a 30% and 50% reduction in disease risk, relative to carriers of the more common TT genotype (p-trend=0.02). Two additional SNPs also resulted in consistent findings (rs9296925: p-trend=0.07 and rs9370729: p-trend=0.08), although the effects observed did not reach statistical significance at the 0.05 level. Pooled evaluation of cases from the two aforementioned studies suggested differences in the distribution of susceptibility alleles by histology; adenocarcinoma cases were more likely to be carriers of the susceptibility alleles for SNP rs9370729 (p-trend=0.02) and SNP rs750749 (p-trend=0.09). No differences were observed in the age or stage of diagnosis of carriers for CD83 susceptibility alleles relative to non-carriers.ConclusionsWe confirm an association between CD83 polymorphisms and cervical cancer and suggest the possibility that CD83-disease associations might be heterogenous by tumor histology.

Dataset Information

MMP-2 and MMP-9 gene polymorphisms associated with cervical cancer risk.

Publications

<i>MMP-2</i> and <i>MMP-9</i> gene polymorphisms associated with cervical cancer risk.

Similar Datasets

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