Ontology highlight
ABSTRACT:
SUBMITTER: Boguslawska J
PROVIDER: S-EPMC6966432 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Bogusławska Joanna J Popławski Piotr P Alseekh Saleh S Koblowska Marta M Iwanicka-Nowicka Roksana R Rybicka Beata B Kędzierska Hanna H Głuchowska Katarzyna K Hanusek Karolina K Tański Zbigniew Z Fernie Alisdair R AR Piekiełko-Witkowska Agnieszka A
Cancers 20191120 12
Metabolic reprogramming is one of the hallmarks of renal cell cancer (RCC). We hypothesized that altered metabolism of RCC cells results from dysregulation of microRNAs targeting metabolically relevant genes. Combined large-scale transcriptomic and metabolic analysis of RCC patients tissue samples revealed a group of microRNAs that contribute to metabolic reprogramming in RCC. miRNAs expressions correlated with their predicted target genes and with gas chromatography-mass spectrometry (GC-MS) me ...[more]