Ontology highlight
ABSTRACT:
SUBMITTER: Woo SM
PROVIDER: S-EPMC6966507 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Woo Seon Min SM Seo Seung Un SU Kim Sang Hyun SH Nam Ju-Ock JO Kim Shin S Park Jong-Wook JW Min Kyoung-Jin KJ Kwon Taeg Kyu TK
Cancers 20191206 12
<b>:</b> Hispidulin, a natural compound present in herbs, has anti-cancer effects. Here, we investigated whether hispidulin sensitizes human carcinoma cells to apoptosis induced by TRAIL. Sub-lethal dosages of TRAIL alone and hispidulin alone does not increase apoptosis, but hispidulin increases sensitivity to TRAIL, resulting in induction of apoptosis in hispidulin plus TRAIL-treated cancer cells. In addition, combined treatment with hispidulin and TRAIL also reduced tumor growth and increased ...[more]