Ontology highlight
ABSTRACT:
SUBMITTER: Torres-Ayuso P
PROVIDER: S-EPMC6966563 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Torres-Ayuso Pedro P Brognard John J
Cancers 20191207 12
Protein kinases are critical regulators of signaling cascades that control cellular proliferation, growth, survival, metabolism, migration, and invasion. Deregulation of kinase activity can lead to aberrant regulation of biological processes and to the onset of diseases, including cancer. In this review, we focus on oncogenic kinases and the signaling pathways they regulate that underpin tumor development. We highlight genomic biomarker-based precision medicine intervention strategies that match ...[more]