Ontology highlight
ABSTRACT:
SUBMITTER: Panneerselvam J
PROVIDER: S-EPMC6966580 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Panneerselvam Janani J Srivastava Akhil A Mehta Meghna M Chen Allshine A Zhao Yan D YD Munshi Anupama A Ramesh Rajagopal R
Cancers 20191127 12
Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits GLI1 and the associated DDR pathway in human NSCLCs. IL-24 treatment reduces mRNA and protein expression of GLI1 in lung tumor cells, but not in normal cells. GLI1 reporter assay and mRNA studies demonstrated that IL-24 regulates GLI1 at the post-transcriptional level by favoring mRNA d ...[more]