Ontology highlight
ABSTRACT:
SUBMITTER: Grech-Sollars M
PROVIDER: S-EPMC6966628 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Grech-Sollars Matthew M Ordidge Katherine L KL Vaqas Babar B Davies Claire C Vaja Vijay V Honeyfield Lesley L Camp Sophie S Towey David D Mayers Helen H Peterson David D O'Neill Kevin K Roncaroli Federico F Barwick Tara D TD Waldman Adam D AD
Cancers 20191207 12
The cellular and molecular basis of choline uptake on PET imaging and MRS-visible choline-containing compounds is not well understood. Choline kinase alpha (ChoKα) is an enzyme that phosphorylates choline, an essential step in membrane synthesis. We investigate choline metabolism through 18F-fluoromethylcholine (18F-FMC) PET, MRS, and tissue ChoKα in human glioma. Fourteen patients with a suspected diffuse glioma underwent multimodal 3T MRI and dynamic 18F-FMC PET/CT prior to surgery. Co-registe ...[more]