Ontology highlight
ABSTRACT:
SUBMITTER: Neve A
PROVIDER: S-EPMC6966681 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Neve Anuja A Migliavacca Jessica J Capdeville Charles C Schönholzer Marc Thomas MT Gries Alexandre A Ma Min M Santhana Kumar Karthiga K Grotzer Michael M Baumgartner Martin M
Cancers 20191210 12
In the Sonic Hedgehog (SHH) subgroup of medulloblastoma (MB), tumor initiation and progression are in part driven by smoothened (SMO) and fibroblast growth factor (FGF)-receptor (FGFR) signaling, respectively. We investigated the impact of the SMO-FGFR crosstalk on tumor growth and invasiveness in MB. We found that FGFR signaling represses GLI1 expression downstream of activated SMO in the SHH MB line DAOY and induces <i>MKI67</i>, <i>HES1</i>, and <i>BMI1</i> in DAOY and in the group 3 MB line ...[more]