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Preoperative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer.

ABSTRACT: The tumour microenvironment (TME) is recognised as an important prognostic characteristic and therapeutic target in patients with colorectal cancer (CRC). However, assessment generally utilises surgically resected specimens, precluding neoadjuvant targeting. The present study investigated the feasibility of intra-epithelial CD3+ T-lymphocyte density and tumour stroma percentage (TSP) assessment using preoperative colonoscopic biopsies from 115 patients who had undergone resection of stages I-III CRC, examining the relationship between biopsy and surgically resected specimen-based assessment, and the relationship with cancer-specific survival (CSS). High biopsy CD3+ density was associated with high CD3+ density in the invasive margin, cancer stroma and intra-epithelial compartments of surgically resected specimens (area under the curve?>?0.62, p?0.7 (p?

SUBMITTER: Park JH 

PROVIDER: S-EPMC6966701 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Preoperative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer.

Park James H JH   van Wyk Hester H   McMillan Donald C DC   Edwards Joanne J   Orange Clare C   Horgan Paul G PG   Roxburgh Campbell Sd CS  

The journal of pathology. Clinical research 20191014 1

The tumour microenvironment (TME) is recognised as an important prognostic characteristic and therapeutic target in patients with colorectal cancer (CRC). However, assessment generally utilises surgically resected specimens, precluding neoadjuvant targeting. The present study investigated the feasibility of intra-epithelial CD3<sup>+</sup> T-lymphocyte density and tumour stroma percentage (TSP) assessment using preoperative colonoscopic biopsies from 115 patients who had undergone resection of s  ...[more]

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