Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC6966882 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Li Baiyuan B Yin Fang F Zhao Xuanyu X Guo Yunxue Y Wang Weiquan W Wang Pengxia P Zhu Honghui H Yin Yeshi Y Wang Xiaoxue X
Frontiers in microbiology 20200110
Colistin is considered the last-resort antibiotic used to treat multidrug resistant bacteria-related infections. However, the discovery of the plasmid-mediated colistin resistance gene, <i>mcr-1</i>, threatens the clinical utility of colistin antibiotics. In this study, the physiological function of MCR-1, which encodes an LPS-modifying enzyme, was investigated in <i>E. coli</i> K-12. Specifically, the impact of <i>mcr-1</i> on membrane permeability and antibiotic resistance of <i>E</i>. <i>coli ...[more]