Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC6968633 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Deng Xianqing X Song Mingxia M
Journal of enzyme inhibition and medicinal chemistry 20201201 1
Two series of aminoguanidines containing an alkynyl moiety were designed, synthesised, and screened for antibacterial and anticancer activities. Generally, the series <b>3a-3j</b> with a 1,2-diphenylethyne exhibited better antibacterial activity than the other series (<b>6a-6k</b>) holding 1,4-diphenylbuta-1,3-diyne moiety antibacterial activity. Most compounds in series <b>3a-3j</b> showed potent growth inhibition against the tested bacterial strains, with minimum inhibitory concentration (MIC) ...[more]