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Shape-morphing living composites.


ABSTRACT: This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker's yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to a controllable increase in the composite volume of up to 400%. Genetic manipulation of the yeast enables composites where volume change on exposure to l-histidine is 14× higher than volume change when exposed to d-histidine or other amino acids. By encoding an optogenetic switch into the yeast, spatiotemporally controlled shape change is induced with pulses of dim blue light (2.7 mW/cm2). These living, shape-changing materials may enable sensors or medical devices that respond to highly specific cues found within a biological milieu.

SUBMITTER: Rivera-Tarazona LK 

PROVIDER: S-EPMC6968942 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Shape-morphing living composites.

Rivera-Tarazona L K LK   Bhat V D VD   Kim H H   Campbell Z T ZT   Ware T H TH  

Science advances 20200117 3


This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker's yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to a controllable increase in the composite volume of up to 400%. Genetic manipulation of the yeast enables composites where volume change on exposure to l-histidine is 14× higher than volume change when exposed to d-histidine or  ...[more]

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