Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge.
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ABSTRACT:
SUBMITTER: Tatebe H
PROVIDER: S-EPMC6969161 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge.
Tatebe Hisashi H Lim Chew Theng CT Konno Hiroki H Shiozaki Kazuhiro K Shinohara Akira A Uchihashi Takayuki T Furukohri Asako A
Nature communications 20200117 1
The human Mre11/Rad50 complex is one of the key factors in genome maintenance pathways. Previous nanoscale imaging by atomic force microscopy (AFM) showed that the ring-like structure of the human Mre11/Rad50 complex transiently opens at the zinc hook of Rad50. However, imaging of the human Mre11/Rad50 complex by high-speed AFM shows that the Rad50 coiled-coil arms are consistently bridged by the dimerized hooks while the Mre11/Rad50 ring opens by disconnecting the head domains; resembling other ...[more]
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