Hypomania and saccadic changes in Parkinson's disease: influence of D2 and D3 dopaminergic signalling.
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ABSTRACT:
SUBMITTER: Pelzer EA
PROVIDER: S-EPMC6969176 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Hypomania and saccadic changes in Parkinson's disease: influence of D2 and D3 dopaminergic signalling.
Pelzer Esther A EA Dillenburger Barbara B Grundmann Sophie S Iliaev Vladimir V Aschenberg Sophie S Melzer Corina C Hess Martin M Fink Gereon R GR Eggers Carsten C Tittgemeyer Marc M Timmermann Lars L
NPJ Parkinson's disease 20200117
In order to understand the influence of two dopaminergic signalling pathways, TaqIA rs1800497 (influencing striatal D2 receptor density) and <i>Ser9Gly</i> rs6280 (influencing the striatal D3 dopamine-binding affinity), on saccade generation and psychiatric comorbidities in Parkinson's disease, this study aimed to investigate the association of saccadic performance in hypomanic or impulsive behaviour in parkinsonian patients; besides we questioned whether variants of D2 (A1+/A1-) and D3 (B1+/B1- ...[more]
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